Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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6,481 – 6,495 of 178,220 results

6,481

Medchemexpress LLC Ebvaciclib 25mg | 2185857-97-8 | 25 MG

Ebvaciclib is a selective, orally bioavailable inhibitor of cyclin-dependent kinases CDK2, CDK4, and CDK6 that induces cell cycle arrest and apoptosis in preclinical tumor models. The compound shows sub-nanomolar to low-nanomolar binding affinity and is supplied as a high-purity research reagent with recommended solvent and formulation guidance for in vitro and in vivo studies.

Selective inhibitor of CDK2, CDK4, and CDK6.
Orally bioavailable and active in cellular assays.
High potency with sub-nanomolar to low-nanomolar affinity.
Supplied at high purity for research applications.
Soluble in DMSO; example in vivo formulations provided.

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6,482

Medchemexpress LLC Roflupram 10mM 1mL | 1093412-18-0 | 1 ML

Roflupram is a selective, orally active, brain-penetrant phosphodiesterase 4 (PDE4) inhibitor used in research to probe PDE4-mediated signaling and neuropharmacology. It is provided as a ready-to-use solution for laboratory applications and is intended for research use only.

Selective PDE4 inhibitor with reported IC50 ≈ 26.2 nM against human PDE4 catalytic domains.
Brain-penetrant and orally active in preclinical studies.
Supplied as 10 mM solution in DMSO, 1 ML volume for immediate use in assays.
High purity (reported ~99.45%) and well-characterized molecular properties (C16H20F2O4; MW 314.32 g/mol).
Soluble in DMSO at high concentration, suitable for in vitro dosing and formulation work.

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6,483

Medchemexpress LLC 1,5-Isoquinolinediamine, 6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-N1-[3-(trifluorometho... | 2274819-46-2 | 97.1% | 528.49 | 50 MG

LUT014 is a topical BRAF inhibitor designed to address radiation-induced skin damage. It acts by inhibiting BRAF kinase and regulating the MAPK/ERK signaling pathway, promoting the repair and regeneration of damaged skin cells without passing the blood-brain barrier. It is particularly studied for treating radiation dermatitis, especially in breast cancer radiotherapy.

Topical BRAF inhibitor.
Inhibits BRAF kinase and activates MAPK/ERK signaling.
Promotes proliferation of epidermal keratinocytes.
Repairs skin barrier damage caused by radiation.
Alleviates inflammatory responses.
Independent of RAS signaling.
Accelerates repair and regeneration of damaged skin cells.
Suitable for studying radiation dermatitis.
Light yellow to yellow solid appearance.
Storage at 4°C, protected from light.
In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.

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6,484

Selleck Chemical LLC Resatorvid

Resatorvid (TAK-242 CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling blocking LPS-induced production of NO TNF- and IL-6 in macrophages with IC50 of 1 8 nM 1 9 nM and 1 3 nM respectively Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF Resatorvid inhibits autophagy

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6,485

Medchemexpress LLC PROTAC TYK2 degradation agent1 | 2921556-14-9 | C55H69N13O7S | 25 MG

PROTAC TYK2 degradation agent1 is a potent and subtype-selective TYK2 degrader with a DC50 value of 14 nM for TYK2 degradation activity. It is intended for research use, particularly in the study of autoimmune diseases.

Potent and subtype-selective TYK2 degrader
DC50 value of 14 nM for TYK2 degradation activity
Selectively suppresses TYK2 protein levels
Effectively induces degradation of TYK2 in a dose-dependent manner at low concentrations
Can be used for research of autoimmune diseases

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6,486

Medchemexpress LLC Refametinib | 923032-37-5 | 99.8% | 572.34 | 100 MG

Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor. It selectively binds directly to an allosteric pocket in the MEK1/2 enzymes and potently inhibits MEK activity in enzyme inhibition assays.

Potent MEK1/MEK2 inhibitor with IC50s of 19 nM for MEK1 and 47 nM for MEK2
Active in human tumor xenograft models
Well tolerated within therapeutic exposure range in animals

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6,487

Medchemexpress LLC 4-cyano-N-cyclopropyl-N-(thiophen-2-ylmethyl)benzamide | 1210906-48-1 | 99.8% | 282.36 | 5 MG

MR837 is an inhibitor of NSD2-PWWP1, designed to bind with the PWWP domain of human nuclear receptor binding SET domain protein 2. This compound is intended for research use only.

Inhibits NSD2-PWWP1
Binds to human nuclear receptor binding SET domain protein 2 (PWWP domain)
High purity of 99.8%
Suitable for in vitro and in vivo studies with various solubility protocols
Stable in powder form for up to 3 years at -20°C

Pricing & Availability

6,488

Medchemexpress LLC (R)-5,7-difluorochroman-4-ol | 1270294-05-7 | MFCD09763634 | 100.0% | 186.16 g/mol | C9H8F2O2 | 100 G

(R)-5,7-Difluorochroman-4-ol is a chiral drug intermediate used in medicinal chemistry and synthetic research for the preparation of pharmaceutically active compounds. It is supplied as a high-purity enantiomer suitable for laboratory synthesis and analytical work.

High purity suitable for synthetic applications and analytical work.
Molecular formula C9H8F2O2 and molecular weight 186.16 g/mol.
Available in multiple pack sizes including 100 G for scale-up or bulk use.
Commonly used as an intermediate in the synthesis of drug candidates.
Supplied as the (R)-enantiomer for stereoselective synthesis.

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6,489

TARGETMOL CHEMICALS INC GSK256073 5MG

Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis. Purity 98.03%

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6,490

Medchemexpress LLC Sulfaquinoxaline (sodium salt) | 967-80-6 | 99.7% | 1 ML

Sulfaquinoxaline sodium salt is an antimicrobial used in veterinary medicine, effective against a broad range of Gram-negative and Gram-positive bacteria. This substance is used to prevent coccidiosis and bacterial infections. It is for research use only.

Antimicrobial for veterinary use
Activity against a broad spectrum of Gram-negative and Gram-positive bacteria
Used to prevent coccidiosis and bacterial infections

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6,491

Medchemexpress LLC Dna-pk-in-8 | 2823369-81-7 | 99.7% | 394.43 g·mol-1 | C19H22N8O2 | 5 MG

DNA-PK-IN-8 is a potent, selective, orally active inhibitor of DNA-dependent protein kinase used in preclinical research to probe DNA repair mechanisms, assess cancer cell response, and evaluate combination therapies. It shows subnanomolar potency and has demonstrated antiproliferative and tumor-growth suppression activity in model systems.

Potent inhibition of DNA-PK (IC50 0.8 nM).
High purity suitable for research applications.
Orally active in preclinical models.
Useful for DNA repair and oncology studies.
Available in small-quantity packages for laboratory use.

Pricing & Availability

6,492

eMolecules 100516-62-9 | Ambeed | 123456-Hexakis[2-(trimethylsilyl)ethynyl]benzene | 100mg | 598443036 | A1154806 | 655.338 | C36H54Si6

Pharmablock | tert-butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate | 25mg | 551196955 | PB02644 | 1008526-71-3 | MFCD17015986 | 202.254 | C9H18N2O3

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool

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6,493

Medchemexpress LLC Idh-305 | 1628805-46-8 | MFCD31630851 | 99.2% | 490.45 g·mol⁻¹ | C23H22F4N6O2 | 100 MG

IDH-305 is an orally available, mutant-selective, brain-penetrant small-molecule inhibitor of isocitrate dehydrogenase 1 (IDH1) that targets oncogenic R132 mutations. It exhibits strong selectivity for mutant IDH1 isoforms and nanomolar potency against common variants, making it suitable for cellular and in vivo studies of IDH1-driven disease.

Mutant-selective IDH1 inhibition with nanomolar potency against common R132 variants.
Brain-penetrant compound suitable for central nervous system models.
High selectivity versus wild-type enzyme, supporting target-specific studies.
High purity suitable for research use.
Solubility and formulation data available for in vitro and in vivo applications.
Stable under recommended storage conditions for long-term use.

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6,494

Medchemexpress LLC Lacritin Human His 10ug

Recombinant human Lacritin (A19-A138) with an N-terminal 6xHis tag, supplied as a lyophilized powder for research use. The protein is expressed in E. coli, purified to high purity with low endotoxin, and provided with storage and reconstitution guidance for biochemical and cell-based studies.

Recombinant fragment A19-A138 with N-terminal 6xHis tag.
Expressed in E. coli for efficient production.
Purified to greater than 95% for reliable analytical and functional assays.
Lyophilized formulation for extended shelf life and convenient storage.
Low endotoxin level (<1 EU/μg) suitable for many cell-based applications.
Reconstitution recommended at ≥100 μg/mL; aliquot and store at -20 °C or -80 °C.
Approximately 23.0 kDa molecular weight for analytical confirmation.

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6,495

Apexbio Technology LLC TGX-221 663619-89-4 5mg

TGX-221 (CAS 663619-89-4) is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) p110 isoform exhibiting an IC50 of 8 5 nM In cellular studies TGX-221 reduces insulin-stimulated phosphorylation of protein kinase B (PKB/Akt) at Ser473 in J774 2 macrophages without affecting PKB phosphorylation in CHO-IR or 3T3-L1 cells In vivo TGX-221 administration in murine models of arterial thrombosis increases blood flow and prolongs bleeding times and reduces mortality rates in rat thrombus models TGX-221 is utilized in research exploring PI3K function in cellular signaling and thrombotic disease mechanisms

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Pyridines and derivatives

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Medchemexpress LLC Ebvaciclib 25mg | 2185857-97-8 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Roflupram 10mM 1mL | 1093412-18-0 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1,5-Isoquinolinediamine, 6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-N1-[3-(trifluorometho... | 2274819-46-2 | 97.1% | 528.49 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Selleck Chemical LLC Resatorvid Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC TYK2 degradation agent1 | 2921556-14-9 | C55H69N13O7S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Refametinib | 923032-37-5 | 99.8% | 572.34 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-cyano-N-cyclopropyl-N-(thiophen-2-ylmethyl)benzamide | 1210906-48-1 | 99.8% | 282.36 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (R)-5,7-difluorochroman-4-ol | 1270294-05-7 | MFCD09763634 | 100.0% | 186.16 g/mol | C9H8F2O2 | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC GSK256073 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfaquinoxaline (sodium salt) | 967-80-6 | 99.7% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dna-pk-in-8 | 2823369-81-7 | 99.7% | 394.43 g·mol-1 | C19H22N8O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Idh-305 | 1628805-46-8 | MFCD31630851 | 99.2% | 490.45 g·mol⁻¹ | C23H22F4N6O2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lacritin Human His 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC TGX-221 663619-89-4 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More